Abstract: 【Objective】The purpose of the study was to analyze the inheritance patterns of wet gluten content， dry gluten content and gluten index of wheat through the analysis of major gene + polygene in heritance model for gluten related traits in wheat， so as to provide theoretical reference for the selection and breeding of red skin strong gluten special wheat varieties in wheat region of the middle and lower reaches of Yangtze River in China.【Method】The doubled haploid（DH）population（189 families in total）constructed with Sumai 6×Yang 97G59 as the parents was used as the material，and inheritance model analysis of wet gluten content，dry gluten content and gluten index of wheat was carried out by using major gene+polygene inheritance segregation analysis.【Result】Wet gluten content in Jurong pilot MX2-ED-A model was the optimal model，which was controlled by 2 pairs of dominant epistatic effect major genes and additive effect and minor-effect polygenes. The heritability of the major gene was 74.18%， and the polygene heritability was 24.35%. But the MX2-IE-A model was the optimal model in Yangzhou pilot， which was controlled by 2 pairs of inhibitory effect major genes and additive effect and minor-effect polygenes. The heritability of the major gene was 7.41%， and the polygene heritability was 90.60%.Dry gluten content in Jurong pilot MX2-ED-A model was the optimal model，which was controlled by 2 pairs of dominant epistatic effect major genes and additive effect and minor-effect polygenes. The heritability of the major gene was 38.24%，and the polygene heritability was 61.61%. In Yangzhou pilot， the MX2-IE-A model was the optimal model， which was controlled by 2 pairs of inhibitory effect major genes and additive effect and minor-effect polygenes. The heritability of the major gene was 5.65%，and the polygene heritability was 94.04%. The gluten index in Jurong pilot MX2-AI-AI model was the optimal model，which was controlled by 2 pairs of additive epistatic effect major genes and additive epistatic effect and minor-effect polygenes. The heritability of the major gene was 66.34%，and that of the polygene was 33.55%. In Yangzhou pilot，the MX2-DE-A model was the optimal model，which was controlled by 2 pairs of overlapping effectmajor genes and additive effect and minor-effect polygenes. The heritability of major gene was 42.05%， and that of polygene was 57.62%.【Conclusion】The dry gluten content，wet gluten content and gluten index of wheat are quantitative characters，which are controlled by multiple genes and have environmental effects. The inheritance of dry glutencontent and wet gluten content is mainly controlled by 2 pairs of dominant epistatic or inhibitory effect major genes+ polygenes. The inheritance of gluten index is controlled by 2 pairs of additive epistatic or overlapping effect major gene+ polygene.