Abstract: Objective In this study,blood routine examination indexes of Guike pigs were detected,number variation and morphology distribution of different functional cells (red blood cells,white cells and platelets) were researched to provide basic reference data for Guike pig immunological evaluation and disease resistance research.Method Fortyfour healthy Guike pigs had been taken blood samples each week since 49 days old and lasted for seven weeks.Their blood routine examination indexes were measured,and compared with those of Landrace pigs and Enshi black pig.Result In red blood cells indexes of Guike pigs of different day ages,red blood cells (RBC) number and hemoglobin (HGB) content were the lowest(6.85× 1012/L and 97.1 g/L) at the age of 70 days,significantly lower than the corresponding value at 49,56,63,84 and 91days old (P<0.05,the same below).The rhythms of mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were basically the same,both were the lowest (15.11 PG and 275.70 g/L) at the age of 70 days,and reached the highest value(16.40 pg and 314.30 g/L) at the age of 91 days.Hematokrit(HCT),mean corpuscular volume(MCV) and red blood cell distribution width(RDW) changed stablely,and there was no significant difference between different ages (P>0.05,the same below).In white blood cells indexes,the total number of white blood cells (WBC) at the age of 63 days was the lowest (13.71 × 109/L),reached the highest value (17.52 × 109/L)at the age of 84 days,there was significant difference between them.Neutrophils (NEUT) reached the the lowest(3.61 × 109/L) at the age of 70 days,significantly lower than the corresponding value of 49 and 56 days old.The change of total lymphocyte count (LYMPH) was relatively stable,it was not significantly affected by the increase of age.In platelet indexes,platelet (PLT) count,plateletcrit (PCT) and platelet distribution width (PDW) were relatively stable at different ages,and they were not significantly influenced by age.Compared with the 35 days old Landrace pigs and 5 months old Enshi black pigs,most of the blood routine indexes of Guike pigs were in between normal blood routine index values of Landrace pigs and enshi black pigs except for a few indexes:HCT,mean platelet volume (MPV),PCT and DW.ConclusionGuike pigs are peculiar in blood routine examination indexes.The pigs at 49-91 days old develop stable immune system.