Abstract: ObjectiveAdaptability, disease resistance and yield of multi-genotype rice varieties in Dehong, Yunnan were evaluated in order to provide reference for promotion of multi-genotype varieties in Yunnan and enrich agricultural biodiversity in Yunnan. MethodMulti-genotype rice varieties Youqun 6,Nanbanuo,Duojixin 15,Duojixin 16,Guangduo 18 and Guangyou 1 were chosen to conduct field experiment through the comprehensive evaluating growth period, disease resistance, agronomic traits, yield and other indicators in comparison of single-genotype indica variety Hongyou 7(control) in Mangshi, Dehong, a indica planting area in yunnan. ResultThe results showed that for Multi-genotype rice varieties, rice blast index was between 0.41-2.49,belonging to light occurrence; false smut index was between 3.23-7.62,belonging to light occurrence. Bacterial blight disease did not occurred in field. The varieties had small variable coefficient(3.25-4.56) on plant height and the agronomic traits were consistent. The grain yields (9459.0-10960.5 kg/ha ) of tested varieties were significantly(P<0.05) higher than that of control. ConclusionThe six multi-genotype rice varieties show sound field uniformity, stable agronomic characters, strong adaptability, and satisfactory disease resistance, high yield and stability. Therefore, these varieties are suitable for planting in Dehong, Yunnan.