Abstract: ObjectiveThe experiment was conducted to determine the optimal appliation rate of nitrogen,phosphorus and potassium fertilizers on hybrid maize Guidan 162 in order to increase its potential yield and provide a scientific basis for its further promotion in Guangxi. MethodUsing 3414 fertilizer experiment design, fertilizer effect function was es-tablished and function effect was solved. Effects of different fertilization levels on maize yield and the optimal fertilization amount when maize reaching optimum sustainable yield were analyzed. ResultThe effects of different parameters on yield of maize are as follows:N>K2O>P2O5. In different-kind fertilizer effect functions, the maximum yield was 8390.8 kg/ha cal-culated with ternary quadratic equation. The fertilizer cost (2959.9 yuan/ha) was low, input-output ratio (5.67) was high. Although optimum sustainable yield(7145.5 kg/ha) was low, fertilizer cost(2022.9 yuan/ha) was the lowest among all functions and input-output ratio(7.07) was the highest. Conclusion3414 experiment design scheme can be adopted to optimize fertilization of maize variety Guidan 162. The recommended fertilization parameters of maize obtained from ternary quadratic equation was N 176.8 kg/ha,P2O5 63.1 kg/ha,K2O 96.3 kg/ha. The optimum sustainable yield is 7145.2 kg/ha,and the input-output ratio is 7.07.