Abstract: ObjectiveAntibacterial effects of Rheum,Rhus chinensis,Coptis chinensis and Prunus mume on Aeromonas hydrophila of different resources were analyzed using Meta analysis method in order to provide reference for selecting trditional Chinese medicines and corresponding compounds which could prevent and control A.hydrophila.MethodThe researcher searched literature from CNKI data base ranging from the day establishing the data base to May,2016 on computer.Papers on in vitro inhibition of Rheum,R.chinensis,C.chinensis and P.mume on A.hydrophila were searched,and references mentioned in the papers were also tracked down.Meta analysis on the extracted data was conducted using RevMan 5.3.ResultNine papers were analyzed through Meta analysis,the results showed that:antibacterial effects of R.chinensis were significantly stronger than those of RheumMD=8.11,95% CI(6.26,9.95),P<0.00001;antibacterial effects of C.chinensis were significantly weaker than those of RheumMD=-3.41,95% CI(-5.61,-1.21),P=0.002;antibacterial effects of P.mume were significantly stronger than those of RheumMD=6.43,95% CI(5.18,7.69),P<0.00001;antibacterial effects of P.mume were significantly weaker than those of R.chinensisMD=-9.34,95% CI(-18.14,-0.54),P=0.04;antibacterial effects of C.chinensis were significantly weaker than those of R.chinensis MD=-10.81,95% CI (-12.64,-8.97),P<0.00001.Sensitivity analysis showed that Meta analysis results were stable.ConclusionAmong the four traditional Chinese medicines,the antibacterial effects on A.hydrophila are R.chinensis>P.mume>R.>C.chinensis.The results are stable.In terms of compatibility of traditional Chinese medicines or Chinese and western medicines that preventing and controlling A.hydrophila in the future,R.chinensis and P.mume should be considered.