Abstract: 【Objective】 To study the composting method of Tithonia diversifolia and its application effects on different crops， which could provide theoretical basis for the resource utilization of this invasive plant species， with the aim of achieving the goal of comprehensive control through utilization. 【Method】 The stems and leaves of Tithonia diversifolia and maize stalks were crushed and mixed. They were then subjected to composting with and without microbial agents. The organic matter and nutrient contents of the compost were determined. Field experiments were conducted using tested crops （maize， tobacco， potato， and lettuce）. The Tithonia diversifolia compost with microbial agents （MOF）， Tithonia diversifolia compost without microbial agents （OF）， and the conventional compound fertilizer （NPK） were applied respectively. No fertilization was used as a blank control （CK）. The growth indicators of the crops， leaf photosynthetic para-meters， nutrient contents， and yields were measured. 【Result】 Adding microbial agents to the compost of Tithonia diversifolia resulted in a 12.14% increase in total nutrient content compared to the treatment without adding microbial agents， and increased the contents of organic matter， total nitrogen， total phosphorus， and total potassium by 6.63%， 8.80%， 11.66%， and 14.41% respectively. MOF treatment showed better promotion effect on crop growth than OF treatment in four tested crops. Compared with CK， the relative chlorophyll content （SPAD values） and net photosynthetic rates of leaves of the four crops treated with OF and MOF treatments were significantly increased （P<0.05， the same below）， and the accumulations of nitrogen， phosphorus and potassium nutrients in the aboveground parts were also significantly increased. The promoting effects of different treatments on the yields of the four crops were all NPK > MOF > OF > CK， and yield of the four crops in MOF and OF treatments were significantly higher than CK. There were differences in the yield promoting effects of applying the compost of Tithonia diversifolia. Under the MOF and OF treatments， the yield increase rate of lettuce was the highest， at 36.64% and 28.44% respectively， followed by that of tobacco， at 22.87% and 15.02% respectively， and the yield increase rate of potato was the lowest， at 12.73% and 8.86% respectively. 【Conclusion】 Using the stems and leaves of Tithonia diversifolia for composting can achieve the resource utilization of organic waste in the process of controlling Tithonia diversifolia. The addition of microbial agents during the composting process has better effects. The compost of Tithonia diversifolia can promote the growth of crops and increase yields when applied in the production of lettuce， maize， potato and tobacco， and the application effect is the best on lettuce.