Abstract: 【Objective】To study the effects of inoculation of different rhizosphere growth-promoting bacteria(PGPR) on the microecological environment and growth status of rhizosphere soil of Peucedanum praeruptorum Dunn, so as to provide a reference for the development of microbial fertilizer resources and the quality improvement of P. praeruptorum.【Method】Nine PGPR inoculations were used to inoculate the plants at room temperature: S1 treatment inoculated with Bacillus thuringiensis, S2 treatment inoculated with Paenibacillus amylolyticus, and S3 treatment inoculated with B. polymyxa), S4 treatment inoculated with B. aryabhattai(screening site was Sichuan), S5 treatment inoculated with B. aryabhattai(screening site Yunnan), S6 treatment inoculated with B. cereus, S7 treatment inoculated with B. mycoides, S8treatment inoculated with B. proteolyticu, S9 treatment inoculated with B. wiedmannii. The cultivation substrate was sterilized without inoculation as a control(CK). The differences in the number of microorganisms, physicochemical traits, enzyme activities and plant growth indexes in the rhizosphere of P. praeruptorum after inoculation with different PGPR were compared and analyzed, and the correlation analysis of soil physicochemical properties, microbial number and growth indexes was carried out. 【Result】Inoculation with different PGPR had a certain effect on the number of microorganisms in the rhizosphere soil of P. praeruptorum. The number of bacteria, fungi, actinomycetes, inorganic phosphate-solubilizing bacteria, organic phosphate-solubilizing bacteria and potassium-solubilizing bacteria increased by 295.63%, 134.32%, 48.17%, 81.42%, 251.70% and 81.20% respectively compared with the CK. After PGPR inoculation, the p H of rhizosphere soil was higher than that of CK, and the contents of alkali-hydrolyzable nitrogen, available phosphorus, available potassium(except S7 treatment) and organic matter in rhizosphere soil were also increased to varying degrees, and the overall soil trait indexes of S6 treatment were fine. PGPR inoculation increased the activities of protease, phosphatase and sucrase in the rhizosphere soil of P. praeruptorum, and the overall enzyme activity indexes treated with S8 were fine.From the perspective of growth indexes, compared with CK, the plant height and stem diameter of P. praeruptorum increased, the leaf lengthened and the leaf area increased, and the leaf width and petiole length of most treatments increased after PGPR inoculation. The results of correlation analysis showed that rhizosphere soil pH was significantly positively correlated with leaf width(P<0.05, the same below), the available phosphorus content was extremely significantly positively correlated with stem diameter(P<0.01, the same below), the available potassium content was significantly positively correlated with petiole length, the organic matter content was extremely significantly positively correlated with leaf length and leaf area, and was significantly positively correlated with leaf width and petiole length, the number of bacteria was significantly positively correlated with plant height, and the number of organic phosphate-solubilizing bacteria was significantly positively correlated with stem diameter. 【Conclusion】Inoculation with PGPR can change the microbial community structure of the rhizosphere soil of P. praeruptorum, effectively increase the activity and nutrient content of soil enzymes in the rhizosphere, improve the growth of P. praeruptorum, and enhance soil fertility. Among them, inoculation of B. proteolyticu and B. cereus is more effective.