Abstract: 【Objective】 In order to explore the regulatory characteristics of sulfur coated slow-release fertilizer on yield,quality and nitrogen efficiency of different red skinned strong gluten wheat varieties,and to provide reference for the scientific application of slow-release fertilizer in wheat production.【Method】 Four red skinned strong gluten wheat varieties(Zhenmai 12,Yangfumai 101,Sumai 11 and Nongmai 88)were used as experimental materials. Under the condition of equal nitrogen application rate(225 kg/ha pure nitrogen),the fertile formulae were 100% slow-release fertilizer(Q)and 60% slow-release fertilizer+40% urea(H). The three base to dress ratio levels were 10:0,7:3 and 5:5. The conventional fertilization mode(basal:tillering:jointing:booting as 5:1:2:2)was set as a control(CK). The differences of the different modes on yield,quality and nitrogen efficiency of wheat were analyzed.【Result】 The results showed that the single fertilization of sulfur coated slow-release fertilizer had a better effect on increasing the yield of four wheat varieties compared with CK,and the yield increase effect of Q3 treatment(fertilizer ratio was Q,base to dress ration was 5:5)was the best,with an average yield of 7.93%. The factor that directly affected the most the yield of the four varieties was 1000-kernel weight,followed by thekernels per spike(Yangfumai 101,Nongmai 88)or the spike number(Zhenmai 12,Sumai11). Q3 treatment was the highest in agronomic efficiency of nitrogen fertilizer and partial productivity of nitrogen fertilizer. The recovery efficiency of nitrogen fertilizer in H3 treatment(fertilizer ratio was H,base to dress ration was 5:5)was relatively high. Variety,fertilizer ratio and base to dress ratio on wheat-related quality indicators have significant(P<0.05)or extremely significant(P<0.01)effects. The flour extraction rate was higher in CK and H1(fertilizer ratio was H,base to dress ration was 10:0)treatments. The protein content,wet gluten,sedimentation value were higher in CK and H3 treatments. The dough stability time was higher in CK and Q3 treatments. The comprehensive traits in H3 treatment was the best.【Conclusion】 Therefore,100% sulfur coated slow-release fertilizer can achieve high yield,labor-saving with basic fertilizer:re-greening fertilizer is 5:5. And 60% slow-release fertilizer+40% urea canincrease grain yield,improve quality and achieve high quality and nitrogen efficient synergistic development with basic fertilizer:re-greening fertilizer is 5:5. These two methods can be recommended fertilization mode as wheat following rice.