Abstract: 【Objective】The relationship between sensory quality and main chemical component of flue-cured cigarette was studied, in order to provide theoretical basis for the production of flue-cured cigarette.【Method】The contents of smoke nicotine, tar, carbon monoxide, and sensory quality scores of 275 flue-cured cigarette standard samples were researched as the objects, the correlation analysis, regression analysis, path analysis and canonical correlation analysis were conducted.【Result】The averages of tar, carbon monoxide and smoke nicotine content of flue-cured cigarette were 11.39, 12.39 and 0.96 mg/cigarette, and the coefficients of variation were 19.35%, 20.02% and 21.72%, respectively. The coefficient of variation of offensive odor in flue-cured cigarette sensory quality index was the highest(10.76%), whereas the coefficient of variation of other indicators were less than 10.00%. The five sensory indicators had extremely significant negative correlation with carbon monoxide content(P<0.01, the same below), which had extremely significant positive correlation with smoke nicotine content. The offensive odor had significant negative correlation with tar content(P<0.05, the same below). The direct and indirect impact of smoke nicotine content on cigarette sensory indicators were great by the path analysis. There were extremely significant multiple linear regression relationships between sensory indicators and the three smoke chemical components by the regression analysis. The grey correlation order of main smoke chemical components and aroma, humorous, irritation, aftertaste were tar content>smoke nicotine content>carbon monoxide content, whereas the grey correlation order of main smoke chemical components and offensive odor were smoke nicotine content>tar content>carbon monoxide content. The three typical variables of the main smoke chemical components and sensory indexes of cigarette samples were statistically significant.【Conclusion】The direct impact of smoke nicotine content on cigarette sensory quality of flue-cured cigarette is great, and tar content is closely related to cigarette aroma, humorous, irritation and aftertaste in sensory quality indicators. The relationship between main smoke chemical component and sensory quality should be coordinated in the production of flue-cured cigarette. Moreover, the measures should be taken to maintain stability of sensory quality, while reducing tar content and harm in cigarette production.