Abstract: 【Objective】The research was conducted to study effects of different fertilization modes of selenium on yield, effects of the seleniumenrichment and qualities of winter cropping potatoes to provide reference for standardized selenium-enriched potato cultivation techniques.【Method】The field test was carried out with variety Xuechuan 3 as the research material, with 6000 kg/ha ordinary organic fertilizer and 1500 kg/ha compound fertilizer as the control. In addition, eight different ratios of selenium-enriched high calcium type organic fertilizer, compound fertilizer and amino acid chelate foliar fertilizer treatment groups were set. The yield, selenium content and quality character indexes of potato under different treatments were determined and the cost and benefit were accounted.【Result】Both selenium-enriched high calcium type organic fertilizer and amino acid chelated selenium foliar fertilizer could improve potato yield and tuber selenium content to varying degrees, and the selenium-enriching effect of spraying amino acid chelated selenium foliar fertilizer was better than applying selenium-enriched high-calcium organic fertilizer, but the potato yield and the selenium content of tubers were not directly proportional to the concentration of selenium fertilizer. With concentration of 6000 kg/ha selenium-enriched high-calcium organic fertilizer+1500 kg/ha compound fertilizer+6000 mL/ha amino acid chelated selenium foliar fertilizer, the potato yield was the highest(41.08 t/ha), and the selenium content in potato tubers was also higher. Spraying selenium fertilizer had a certain promoting effect on increasing potato tuber starch content, protein content and vitamin C, but had no significant effect on reducing sugars(P>0.05). Correlation analysis found that there was significant (P<0.05, the same below) or extremely significant(P<0.01) positive correlation between selenium content of potato and protein, vitamin C and dry matter accumulation. Compared with CK, the application of selenium-rich organic fertilizer with high calcium content and amino acid chelated selenium foliar fertilizer had considerable economic benefits, and the application of 6000 kg/ha selenium-enriched high-calcium organic fertilizer+1500 kg/ha compound fertilizer+6000 mL/ha amino acid chelated selenium foliar fertilizer had the highest planting benefits, which reached 119052.0 yuan/ha.【Conclusion】Selenium-enriched high-calcium organic fertilizer and amino acid chelated selenium foliar fertilizer can promote the selenium content, starch content, protein content and vitamin C content in of potato tuber. 6000 kg/ha seleniumenriched high-calcium organic fertilizer+1500 kg/ha compound fertilizer+6000 mL/ha amino acid chelated selenium foliar fertilizer has fine effects. It can balance potato yield and quality, and meet the requirements of selenium content classification of local selenium-rich agricultural products in Guangxi.