Abstract: ObjectiveAppropriate tobacco varieties for Dejiang County were screened to provide references for sus-tainable development of flue-cured tobacco production in Dejiang.MethodThe main varieties,Yunyan 87 and K326,in Liqun Jiancha Base of China Tobacco Zhejiang Industrial Co.,Ltd.,in Dejiang,Guizhou were used as control.Compre-hensive evaluation of agronomic traits,disease resistance,economic characters and quality of tobacco leaves among the ten approved tobaco varieties(Yunyan 110,PHV1452,KRK26,Zhongyan 100,Zhongyan 101,Jinhai No.1,Guiyan No.4,Bina No.1,Guiyan 201,Guiyan 202,Yunyan 87,and K326)were conducted using hierarchical clustering analy-sis and principal component analysis methods.ResultGuiyan 202 had the optimal agronomic traits among the all tested varieties.It had high plant height,suitable leaf quantity,long node length,fine width and length of leaf in the middle and the best top leaf expand degree.The agronomic traits of Zhongyan 100 ranked the second.For Bina No.1,Yunyan 110, PHV1452 and Zhongyan 101,indcidence rates of climate spot,red star disease,mosaic,bacterial wilt,and black shank disease were low,and the comprehensive disease resistance was strong.The economic character of Jinhai No.1 was the best(output value 39636.0 yuan/ha),which was significantly higher than the two controls(P<0.05,the same below).The economic characters of Bina No.1 and Zhongyan 101 ranked the second and the third,whose output values were 38046.0, and 37054.5 yuan/ha respectively.Their output values were significantly higher than the control K326.For Guiyan 202, Zhongyan 101,Yunyan 110 and Guiyan No.4,the nicotine,total soluble sugar,reducing sugar,total nitrogen,total chlorine,sugar/nitrogen,nitrogen/nicotine were in suitable range,and their aroma characteristics,smoke characteristics, texture characteristics and total score of smoking quality were fine.ConclusionZhongyan 101,Guiyan 202 and Guiyan 4 present fine performance in growth condition in field,disease resistance,economic characters and smoking quality,and they are suitable for planting in Dejiang,Guizhou.