Abstract: The pathogenic mechanism of many plant pathogens depends on the regulation of quorum sensing systems in the pathogenic microbial population.Therefore,screening of highly efficient drugs based on the principle of quorum sensing inhibition was expected to be an effective way to solve the problems in plant disease control.This paper intro-duced the research strategies of quorum sensing inhibition(QSI),which mainly included blocking the generation of quo-rum signaling molecules,promoting the degradation of signal molecules and inhibiting the binding of signaling molecules to the receptors.The main groups of inhibitors and their application in plant disease prevention and control in recent years were reviewed.Based on the reviews,the paper pointed out that QSIs did not prevent the normal growth and metabolism of pathogens,but inhibited the quorum sensing system,reducing the virulence of pathogens and lowering its pathogenici-ty. Besides,it was suggested that screening of QSIs and plant disease prevention and control based on quorum sensing quenching mechanism should be strengthened to provide new green and safe control measures for plant disease prevention and control in the future.