Abstract: ObjectiveThe extraction parameters of polysaccharides in sugarcane (Saccharum officinarum L.) tops were optimized to provide references for utilizing sugarcane top polysaccharides. MethodWith polysaccharides yield and DPPH scavenging activity as the indicators, response surface analysis (RSA) was used to optimize the ultrasonic extraction conditions for polysaccharides from sugarcane tops. ResultThe optimal conditions were ultrasonic power of 640 W, ex-traction temperature of 69 ℃, and extraction time of 29 min, under which the extraction yield and the DPPH scavenging rate of polysaccharides was 4.68% and 74.89%, respectively. ConclusionThe response surface methodology was a rea-sonable method to optimize the extraction parameters of sugarcane top polysaccharides.